Abstract Search

ea0035oc6.2 | Bone, calcium & vitamin D | ECE2014

High spontaneous osteoclastogenesis in pediatric osteogenesis imperfecta patients receiving or not intravenous neridronate

Faienza Maria Felicia , Tummolo Albina , Piacente Laura , Fiaschetto Rita , Ciccarelli Maria , Ventura Annamaria , Papadia Francesco , Colucci Silvia , Grano Maria , Cavallo Luciano , Brunetti Giacomina

Background: Osteogenesis imperfecta (OI) is a heritable disease of the connective tissues caused primarily by heterogeneous mutations in the genes encoding for type I collagen. Phenotypically, it is characterized by abnormal bone mineralization, tissue fragility, and skeletal deformities.Objective: The aim of this study was to investigate the osteoclastogenic potential of unfractionated peripheral blood mononuclear cells (PBMCs) from OI patients (mean ag...

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ea0035p762 | Obesity | ECE2014

Higher serum levels of the Wnt-signaling antagonist DKK1 in obese respect to Prader–Willi syndrome

Brunetti Giacomina , Delvecchio Maurizio , Graziano Grugni , Ventura Annamaria , Ciccarelli Maria , Piacente Laura , Colucci Silvia , Cavallo Luciano , Grano Maria , Faienza Maria Felicia

Background: Obesity and in particular visceral adiposity has been related to low bone mineral density (BMD) and greater fracture risk. Subjects with PraderWilli syndrome (PWS) have lower amount of visceral fat than patients with simple obesity, however can develop osteoporosis. A strong relationship between inhibition of the osteoblast formation and induction of the adipocyte differentiation has been demonstrated. Inhibitors of osteoblastogenesis, such as Dickkopf-1 (DKK...

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Endocrine Abstracts

High spontaneous osteoclastogenesis in pediatric osteogenesis imperfecta patients receiving or not intravenous neridronate

Higher serum levels of the Wnt-signaling antagonist DKK1 in obese respect to Prader–Willi syndrome

BiosciAbstracts